The Children's Hospital of Philadelphia
Postdoctoral Research Fellow
The Sabatino Laboratory at the Raymond G. Perelman Center for Cellular and Molecular Therapeutics and the Division of Hematology at The Children’s Hospital of Philadelphia (CHOP) is currently seeking a post-doctoral research fellow. The laboratory focuses on the inherited bleeding disorder, hemophilia. The interests of the laboratory include (1) the study of variants of coagulation factor VIII to understand the biochemical properties of these proteins and to identify novel variants with enhanced function, (2) the development of gene-based therapeutic approaches for treating hemophilia and (3) understanding the immune response to factor VIII.
Current gene therapy strategies in the laboratory include adeno-associated viral (AAV) vector and lipid nanoparticle delivery approaches. In addition, the laboratory is studying various aspects of gene therapy to understand the biology of gene transfer and the fate of the AAV vector DNA after gene delivery.
The Children’s Hospital of Philadelphia Research Institute is world-renowned, leading research breakthroughs and medical innovations for more than 90 years. The Sabatino laboratory is part of the Division of Hematology at CHOP that includes a collaborative group of coagulation researchers. The Penn-CHOP Blood Center for Patient Care and Discovery is a collaborative and inter-departmental program that provides opportunities to interact with researchers from different areas of expertise at the University of Pennsylvania and CHOP. Dr. Sabatino is also a member of the Raymond G. Perelman Center for Cellular and Molecular Therapeutics at CHOP that includes a team of investigators who are committed to developing cell and gene therapy approaches to treat genetic disease.
Candidates must have a PhD and/or MD degree. Experience in molecular biology, cell biology, immunology and mouse models are preferred but not required. Interested applicants are invited to contact Denise Sabatino, Ph.D, [email protected].