The University of North Carolina at Chapel Hill

NIH-Funded Post-Doctoral Research Position in the Wolberg and Flick Labs

The SARS-CoV-2 coronavirus (CoV2) emerged in December of 2019 and has infected more than 178 million people worldwide, with nearly 20% of the cases occurring in the U.S. The associated coronavirus disease (termed COVID-19) varies substantially; some infected individuals are apparently asymptomatic, whereas others experience significant morbidity and mortality. Current data suggest that differences in clinical outcome are dictated by disparities in the host response to infection. One of the most profound host responses in COVID-19 is a coagulopathy characterized by high circulating fibrinogen, D-dimer, and rates of thrombosis. Post-mortem analyses revealed patients with fatal COVID-19 also have substantial extravascular fibrin deposits in the alveolar space. The long-term goal of our research program is to define the cellular and molecular mechanisms linking coagulation and fibrinolytic proteins to the transition from mild disease to severe, debilitating, and deadly COVID-19.
An NIH-funded postdoctoral position is available in the highly collaborative Wolberg and Flick research laboratories within the UNC Blood Research Center at the University of North Carolina at Chapel Hill. Individuals with experience in infectious disease, immunology, or coagulation pathogenesis and interest in interdisciplinary work to drive understanding in this exciting new frontier are encouraged to apply. Work will center on the use of a mouse-adapted SARs-CoV-2 virus in genetic mouse models with coagulation/fibrinolytic factor deficiencies or functional alterations to characterize virus infection, host responses and changes in clinical coagulation readouts. 

For more information, please see: https://unc.peopleadmin.com/postings/195243

UNC Chapel Hill is one of the premier research institutions in the USA, featuring top-ranked Departments, Centers, and Core Facilities. The Wolberg and Flick labs are part of the UNC Blood Research Center (https://www.med.unc.edu/bloodresearchcenter/) located within the UNC School of Medicine. This highly-collaborative and interdisciplinary group includes researchers from the UNC Departments of Pathology and Laboratory Medicine, Medicine, Biochemistry, Pharmacology, and Pharmacy, and neighboring institutions. Our lab emphasizes a culture of diversity, responsibility, independence and collaboration, and shared excitement for scientific discovery.

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