CHAT is Seeking New Phase II Sites, more sites needed


The Children’s Hospital-Acquired Thrombosis (CHAT) study created the first large-scale, multi-institutional registry including pertinent medical data from children with confirmed HA-VTE and matched controls. Data from this registry will be used to define the risk factors for HA-VTE in pediatric patients and to create (Phase I) and validate (Phase II) a risk assessment model and stratified scoring system.

Several HTRS members – Drs. Brian Branchford, Julie Jaffray, and Arash Mahajerin under the mentorship of Drs. Neil Goldenberg, Diane Nugent, Vince Faustino, Guy Young, and Neil Zakai -- have completed Phase I data collection. Analysis is underway for the multivariate risk assessment model.  Additional sites are needed for Phase II to help validate the model and stratified scoring system developed in Phase I.

More than 25 sites have already committed to Phase II but, since pediatric HA-VTE has an overall low incidence, up to 70 sites may be required for adequate power.

Please contact Brian, Julie, and Arash if interested or with any comments or questions:

Brian Branchford, MD:  [email protected]
Julie Jaffray, MD:  [email protected]
Arash Mahajerin, MD, MSCr:  [email protected]

This project is supported by a 2016 HTRS Mentored Research Award, among others.  The CHAT newsletters, designed to keep participating institutions up-to-date, are provided below:

CHAT Newsletters

Fall 2018
Fall 2017
Fall 2016
Summer 2016 (overview of CHAT)