CHAT Consortium Phase II Studies Kick Off in 2020!
The Children’s Hospital-Acquired Thrombosis (CHAT) Consortium created the first large-scale, multi-institutional Registry including pertinent medical data from children with confirmed HA-VTE and non-VTE subjects. Data from this Registry has defined risk factors for HA-VTE in pediatric patients and created risk assessment models (RAMs) that will now be validated in order to develop a stratified scoring system.
Several HTRS members – Drs. Brian Branchford, Julie Jaffray, and Arash Mahajerin, under the mentorship of Drs. Neil Goldenberg, Diane Nugent, Vince Faustino, Guy Young, and Neil Zakai -- in collaboration with USC/CHLA Biostatistics and Johns Hopkins All Children's Hospital Predictive Analytics, have completed Phase I data analysis for the multivariate risk assessment models.
in July 2019, CHAT became a consortium and many sites are in the process of joining the consortium or are in study startup. The CHAT Consortium now has three studies:
1. CHAT Registry: New HA-VTE cases continue to be added
2. CHAT 1901: Prospective validation of the risk assessment model in PICUs (17 sites participating)
3. CHAT 1902 (sister study to CHAT 1901): Testing biomarkers to determine their ability to predict HA-VTE (4 sites participating)
The CHAT studies have been supported by multiple HTRS Mentored Research Awards, among others. The CHAT Newsletters, designed to keep participating or interested institutions up-to-date, are provided below:
Summer 2016 (overview of CHAT)
Brian, Julie, and Arash would be very happy for interested parties to contact them by email with any comments or questions:
Brian Branchford, MD: [email protected]
Julie Jaffray, MD: [email protected]
Arash Mahajerin, MD, MSCr: [email protected]