Research Fellow: Novel Therapeutics for Bleeding Disorder Program (Dr. Samelson-Jones) - Children's Hospital of Philadelphia
5/23/2022 - The Novel Therapeutics for Bleeding Disorder (NoT Bleeding) Program is an institutionally funded effort at the Children’s Hospital of Philadelphia (CHOP) Research Institute to develop new, more effective treatments for patients with bleeding disorders and integrate novel therapies safely into clinical practice. Translational research projects are focused on the use of monoclonal antibodies, gene addition, and gene editing and will be conducted in the laboratories of Dr. Rodney Camire, Benjamin Samelson-Jones, and Lindsey George with extensive collaborations between the groups. Experimental approaches include recombinant protein production and purification, biochemical studies, mammalian and induced pluripotent stem cell culture, AAV vectors, and murine hemostatic models.
The postdoctoral fellow (postdoc) will have a terminal degree PhD, MD, or MD-PhD and will, under the direction/guidance of a mentor (Dr. Samelson-Jones, MD, PhD), assume responsibility for a specific, ongoing research project focused on understanding the interaction between activated factor VIII and IX and how it can be bypassed as a treatment for hemophilia B. The postdoc experience will serve to extend, refine, and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research and will contribute directly to the overall research goals of the project and the research group. Postdocs will be expected to participate in/lead project planning, recording and interpretation/evaluation of data, and communication of results. Postdocs will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions, and presentations at national meetings. Postdoctoral fellows also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.